1Murder by Friendly Fire
One police officer is accidentally shot by another during a raid gone wrong. Dr. Sloan investigates the victim's wife, the shooter, and a conniving lawyer when he suspects foul play.
2Murder Can Be Contagious
A burglar inadvertently becomes infected with a deadly virus. Dr. Sloan and Jesse are subsequently exposed to the virus after Jesse stumbles upon the thief's dead body. Both Mark and Jesse are confined to Mark's home while Steve and Amanda investigate the drug company that manufactured the virus, in the hopes of discovering an antidote before Jesse runs out of time.
3Murder on Thin Ice
A figure skater hires her ex-coach to attack a rival skater. Dr. Sloan tries to prove her guilt.
4X Marks the Murder (1)
Mark, Steve, et al, investigate a string of the so-called ""Casanova"" murders. Dr. Sloan loses his detached perspective when the killer begins calling Mark.
5X Marks the Murder (2)
Mark, Steve, et al, investigate a string of the so-called ""Casanova"" murders. Dr. Sloan loses his detached perspective when the killer begins calling Mark.
6A Model Murder
Dr. Sloan investigates a photographer, the overly protective mother of Jesse's friend's fiancée, in the murder of a private investigator.
7Murder Can Be Murder
A respected cardiologist murders an innocent man in an insurance scam. Dr. Sloan reluctantly investigates his friend.
8An Explosive Murder
A young undercover detective investigates a militia-type organization to solve a terrorist bombing witnessed by Mark. She has to decide whether to risk blowing her cover and warn Dr. Sloan of an attempt on his life or finish her assignment.
9Murder by the Busload
A bus accident brings multiple victims into the hospital. Amanda does the bulk of the investigating when its discovered that a casualty in the accident was actually murdered.
10A Candidate for Murder
His scheming advisor covers up the accidental death of the drug-addicted daughter of a U.S. Senator. Dr. Sloan and Amanda investigate.
11The ABC's of Murder
An ADA sets out on a vendetta against an Asian youth, against both Mark and Steve's advice, after a drive-by shooting at a high school leaves one teacher dead.
12Murder in the Family
Mark's daughter returns after eight years, leaving an abusive husband who later turns up dead.
13In Defense of Murder
When a famous prostitute writes a tell-all book, an executive's job at Community General is in serious jeopardy.
14A History of Murder
Mark investigates a 30-year old murder when the body of his old mentor is discovered entombed in a wall in the hospital.
15Murder Two (1)
Jesse is arrested and charged with murder after a doctor testifying against Jesse in a malpractice suit is poisoned. Mark convinces his old friend, Ben Matlock, to defend Jesse.
16Murder Two (2)
Amanda and Ben investigate the murder of Eric Spindler while Jesse continues to languish in jail.
17Hard-Boiled Murder
Mark aids an old friend, Joe Mannix, in solving a 25-year-old, unsolved murder.
18Murder, Country Style
When a musician is found murdered at a Country Music Awards ceremony, Dr. Sloan and company rush to find the culprit before the show ends and the crowd disappears.
19Delusions of Murder
A devious psychologist uses hypnotism to facilitate his criminal acts, including the murder of his wife.
20A Passion for Murder
An aggressive female pharmaceuticals representative stalks the hospital's new chief of staff after a one-night-stand, hoping to break up his marriage and have him all for herself.
21Blood Brothers Murder
A beach boy involved with a gang member's sister is suspected of murdering him. Mark investigates.
22Physician, Murder Thyself
Dr. Sloan investigates when an unpopular colleague drops dead while performing an operation. Mark investigates his fellow doctors when tests reveal the deceased was poisoned.
23Murder in the Air
Dr. Sloan and Amanda investigate when the co-pilot of the airplance carrying them to a medical conference is murdered and the remainder of the flight crew are incapacitated with a mysterious illness.
24The Merry Widow Murder
A wealthy woman and her boyfriend dupe Mark and plot to murder her husband.
25Comedy is Murder
A bungling comedian seeks revenge on his former partner when he's cheated out of millions.
26The Murder of Mark Sloan
Dr. Sloan is stalked by a mad bomber whom he helped incarcerate. Norman and Mark are the main dissenters in negotiations to sell the hospital to a corporate raider.